AMPK Keeps Tumor Cells from Starving to Death

Cell Stem Cell. 2015 Nov 5;17(5):503-4. doi: 10.1016/j.stem.2015.10.007.


In this issue of Cell Stem Cell, Saito et al. (2015) examine how leukemia-initiating cells react to metabolic stress imposed by different tissue environments. They find that inhibition of the metabolic stress sensor AMP-activated protein kinase (AMPK) led to deranged glucose metabolism and redox homeostasis, resulting in reduced leukemic progression that was further attenuated by dietary restriction.

Publication types

  • Comment

MeSH terms

  • AMP-Activated Protein Kinases*
  • Homeostasis*
  • Humans
  • Oxidation-Reduction


  • AMP-Activated Protein Kinases