Roles of LIM kinases in central nervous system function and dysfunction

FEBS Lett. 2015 Dec 21;589(24 Pt B):3795-806. doi: 10.1016/j.febslet.2015.10.032. Epub 2015 Nov 3.


LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) regulate actin dynamics by phosphorylating cofilin. In this review, we outline studies that have shown an involvement of LIMKs in neuronal function and we detail some of the pathways and molecular mechanisms involving LIMKs in neurodevelopment and synaptic plasticity. We also review the involvement of LIMKs in neuronal diseases and emphasize the differences in the regulation of LIMKs expression and mode of action. We finally present the existence of a cofilin-independent pathway also involved in neuronal function. A better understanding of the differences between both LIMKs and of the precise molecular mechanisms involved in their mode of action and regulation is now required to improve our understanding of the physiopathology of the neuronal diseases associated with LIMKs.

Keywords: LIM kinase 1; LIM kinase 2; Neurodegenerative disease; Neurodevelopmental disease; Neuronal function.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Central Nervous System / cytology
  • Central Nervous System / enzymology*
  • Central Nervous System / physiology*
  • Central Nervous System / physiopathology
  • Central Nervous System Diseases / enzymology*
  • Central Nervous System Diseases / pathology
  • Central Nervous System Diseases / physiopathology*
  • Humans
  • Lim Kinases / metabolism*
  • Neurons / enzymology


  • Lim Kinases