Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 72 (2), 219-26

Adverse Drug Reactions Leading to Urgent Hospital Admission in an Elderly Population: Prevalence and Main Features

Affiliations

Adverse Drug Reactions Leading to Urgent Hospital Admission in an Elderly Population: Prevalence and Main Features

Consuelo Pedrós et al. Eur J Clin Pharmacol.

Abstract

Purpose: To assess the prevalence of urgent hospitalization due to adverse drug reactions (ADRs) in patients aged ≥ 65 years, to compare the in-hospital mortality rates between patients admitted for ADRs and those admitted for other causes, and to describe the ADRs, the used and suspected drugs, and the drug-reaction associations.

Methods: A cross-sectional study was conducted by using the institutional database of the Pharmacovigilance Programme of Bellvitge University Hospital, a 750-bed tertiary care hospital, with information corresponding to a 7-year period. ADR-related admissions of patients aged ≥ 65 years prospectively identified through a systematic daily review of all admission diagnosis were reviewed.

Results: ADRs were suspected to be the main reason for urgent admission in 1976 out of 60,263 patients aged ≥ 65 years (prevalence of ADR-related hospitalization 3.3 % [95 % CI 3.1-3.4 %]). The crude in-hospital mortality rate was 10.2 % in patients with ADR-related admission and 9 % in patients admitted for other causes (p = 0.077). Most patients (86 %) were exposed to polypharmacy, and a drug-drug interaction was suspected in 49 % of cases. The most frequent drug-reaction associations were acute renal failure related to renin-angiotensin system inhibitors, gastrointestinal bleeding caused by antithrombotics and/or non-steroidal anti-inflammatories, and intracranial bleeding induced by vitamin K antagonists.

Conclusions: One out of every 30 urgent admissions of patients aged ≥ 65 years is ADR-related. These ADRs can be as serious and life-threatening as any other acute pathology that merits urgent hospital admission. Most cases involve patients exposed to polypharmacy and result from well-known reactions of a few commonly used drugs.

Keywords: Adverse drug reactions; Elderly; Hospitalization; Pharmacovigilance.

Similar articles

See all similar articles

Cited by 12 articles

See all "Cited by" articles

References

    1. Ann Pharmacother. 2008 Jul;42(7):1017-25 - PubMed
    1. Drug Saf. 2007;30(10):911-8 - PubMed
    1. Eur J Clin Pharmacol. 2014 Apr;70(4):437-43 - PubMed
    1. Arch Gerontol Geriatr. 2005 Jan-Feb;40(1):45-52 - PubMed
    1. PLoS One. 2010 Nov 12;5(11):e13977 - PubMed

LinkOut - more resources

Feedback