The Transporter Classification Database (TCDB): recent advances

Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. doi: 10.1093/nar/gkv1103. Epub 2015 Nov 5.


The Transporter Classification Database (TCDB; is a freely accessible reference database for transport protein research, which provides structural, functional, mechanistic, evolutionary and disease/medical information about transporters from organisms of all types. TCDB is the only transport protein classification database adopted by the International Union of Biochemistry and Molecular Biology (IUBMB). It consists of more than 10,000 non-redundant transport systems with more than 11 000 reference citations, classified into over 1000 transporter families. Transporters in TCDB can be single or multi-component systems, categorized in a functional/phylogenetic hierarchical system of classes, subclasses, families, subfamilies and transport systems. TCDB also includes updated software designed to analyze the distinctive features of transport proteins, extending its usefulness. Here we present a comprehensive update of the database contents and features and summarize recent discoveries recorded in TCDB.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Databases, Protein*
  • Membrane Transport Proteins / chemistry
  • Membrane Transport Proteins / classification*
  • Membrane Transport Proteins / metabolism
  • Sequence Analysis, Protein


  • Membrane Transport Proteins