Bridging the translational gap: collaborative drug development and dispelling the stigma of commercialization

Drug Discov Today. 2016 Feb;21(2):299-305. doi: 10.1016/j.drudis.2015.10.013. Epub 2015 Nov 6.


The current drug discovery and development process is stalling the translation of basic science into lifesaving products. Known as the 'Valley of Death', the traditional technology transfer model fails to bridge the gap between early-stage discoveries and preclinical research to advance innovations beyond the discovery phase. In addition, the stigma associated with 'commercialization' detracts from the importance of efficient translation of basic research. Here, I introduce a drug discovery model whereby the respective expertise of academia and industry are brought together to take promising discoveries through to proof of concept as a way to derisk the drug discovery and development process. Known as the 'integrated drug discovery model', I examine here the extent to which existing legal frameworks support this model.

Publication types

  • Review

MeSH terms

  • Drug Discovery*
  • Drug Industry
  • Technology Transfer
  • Translational Medical Research*