A New Cerebroside From the Fruiting Bodies of Hericium Erinaceus and Its Applicability to Cancer Treatment

Bioorg Med Chem Lett. 2015 Dec 15;25(24):5712-5. doi: 10.1016/j.bmcl.2015.10.092. Epub 2015 Nov 2.

Abstract

A new cerebroside, cerebroside E (1) was isolated from the fruiting bodies of Hericium erinaceus (Hericiaceae). The structure of 1 was elucidated by a combination of extensive spectroscopic analyses, including extensive 2D NMR, HR-MS, and chemical reactions. Compound 1 was evaluated for its applicability to medicinal use in several human diseases using cell-based assays. As a result, compound 1 attenuated cisplatin-induced nephrotoxicity in LLC-PK1 cells and exhibited a significant inhibitory effect on angiogenesis in HUVECs. These results collectively reflect the beneficial effects of compound 1 in cancer treatment.

Keywords: Angiogenesis; Cerebroside; Hericiaceae; Hericium erinaceus; Nephrotoxicity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetylcholinesterase / chemistry
  • Acetylcholinesterase / metabolism
  • Animals
  • Basidiomycota / chemistry*
  • Basidiomycota / metabolism
  • Cerebrosides / chemistry*
  • Cerebrosides / isolation & purification
  • Cerebrosides / pharmacology
  • Fruiting Bodies, Fungal / chemistry
  • Fruiting Bodies, Fungal / metabolism
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • LLC-PK1 Cells
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Molecular Conformation
  • Neovascularization, Physiologic / drug effects
  • Swine

Substances

  • Cerebrosides
  • cerebroside E
  • Acetylcholinesterase