Diet-delivered RNAi in Helicoverpa armigera--Progresses and challenges

J Insect Physiol. 2016 Feb:85:86-93. doi: 10.1016/j.jinsphys.2015.11.005. Epub 2015 Nov 5.


Helicoverpa armigera (the cotton bollworm) is a significant agricultural pest endemic to Afro-Eurasia and Oceania. Gene suppression via RNA interference (RNAi) presents a potential avenue for management of the pest, which is highly resistant to traditional insecticide sprays. This article reviews current understanding on the fate of ingested double-stranded RNA in H. armigera. Existing in vivo studies on diet-delivered RNAi and their effects are summarized and followed by a discussion on the factors and hurdles affecting the efficacy of diet-delivered RNAi in H. armigera.

Keywords: Cotton bollworm; Diet-delivery; Helicoverpa armigera; RNA interference; RNAi; dsRNA uptake.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Insect Control
  • Insect Proteins / genetics
  • Insect Proteins / metabolism
  • Moths / genetics*
  • Moths / metabolism*
  • RNA Interference*
  • RNA, Double-Stranded / genetics
  • RNA, Double-Stranded / metabolism*


  • Insect Proteins
  • RNA, Double-Stranded