Diversity of CRISPR-Cas immune systems and molecular machines

Genome Biol. 2015 Nov 9;16:247. doi: 10.1186/s13059-015-0816-9.

Abstract

Bacterial adaptive immunity hinges on CRISPR-Cas systems that provide DNA-encoded, RNA-mediated targeting of exogenous nucleic acids. A plethora of CRISPR molecular machines occur broadly in prokaryotic genomes, with a diversity of Cas nucleases that can be repurposed for various applications.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptive Immunity / genetics*
  • Animals
  • Bacteria / genetics
  • Bacteria / immunology
  • CRISPR-Cas Systems / genetics*
  • CRISPR-Cas Systems / immunology
  • DNA / genetics
  • Genetic Engineering / methods
  • Genetic Variation / genetics*
  • Genetic Variation / immunology
  • Humans
  • RNA Editing / genetics

Substances

  • DNA