The TDIF signaling network

Curr Opin Plant Biol. 2015 Dec;28:106-10. doi: 10.1016/j.pbi.2015.10.002. Epub 2015 Nov 6.


Plant growth and development are coordinately controlled by intercellular signaling molecules. CLAVATA3 (CLV3)/EMBRYO SURROUNDING REGION-related (CLE) peptides are crucial intercellular signaling molecules that control plant meristem maintenance. CLE peptides are perceived by plasma membrane-located receptor-like kinases, followed by the initiation of intracellular signaling cascades. Recent studies have uncovered these intracellular signaling networks involving signal divergence and integration. This review summarizes recent advances in the study of TDIF peptide signaling pathway, a representative model of CLE peptide signaling, focusing on newly uncovered biological functions and unique signal transduction mechanisms.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Gene Expression Regulation, Plant*
  • Plant Development
  • Plant Physiological Phenomena*
  • Plant Proteins / genetics*
  • Plant Proteins / metabolism
  • Signal Transduction*


  • Plant Proteins