Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer's models

Nat Neurosci. 2015 Dec;18(12):1725-7. doi: 10.1038/nn.4163. Epub 2015 Nov 9.


Among the most promising approaches for treating Alzheimer's disease is immunotherapy with amyloid-β (Aβ)-targeting antibodies. Using in vivo two-photon imaging in mouse models, we found that two different antibodies to Aβ used for treatment were ineffective at repairing neuronal dysfunction and caused an increase in cortical hyperactivity. This unexpected finding provides a possible cellular explanation for the lack of cognitive improvement by immunotherapy in human studies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / immunology*
  • Alzheimer Disease / metabolism
  • Alzheimer Disease / therapy*
  • Amyloid beta-Peptides / immunology*
  • Amyloid beta-Peptides / metabolism
  • Animals
  • Female
  • Humans
  • Immunotherapy / methods*
  • Mice
  • Mice, Transgenic
  • Neurons / immunology*
  • Neurons / metabolism


  • Amyloid beta-Peptides