[Thrombotic thrombocytopenic purpura in a newborn]

Arch Pediatr. 2016 Jan;23(1):78-81. doi: 10.1016/j.arcped.2015.09.032. Epub 2015 Nov 6.
[Article in French]


We report the case of a newborn presenting with hemolytic anemia, thrombocytopenia, hyperbilirubinemia, and renal failure in the first hours of life. An early plasmatherapy was undertaken, with good outcome. The specific von Willebrand factor-cleaving protease activity (ADAMTS 13 for a disintegrin and metalloprotease with thrombospondin type 1 repeats) was found to be low. This is the specific biologic diagnostic element of congenital thrombotic thrombocytopenic purpura (TTP). This disease of constitutional thrombotic microangiopathy is rare. The prognosis, usually life-threatening, was completely transformed given the better understanding of the pathogenesis of the disease and therapeutic progress.

Publication types

  • Case Reports

MeSH terms

  • Anemia, Hemolytic / etiology
  • Humans
  • Hyperbilirubinemia / etiology
  • Infant, Newborn
  • Male
  • Purpura, Thrombotic Thrombocytopenic / complications
  • Purpura, Thrombotic Thrombocytopenic / diagnosis*
  • Renal Insufficiency / etiology
  • Thrombocytopenia / etiology