Diagnostic approach to eosinophilic oesophagitis: Pearls and pitfalls

Best Pract Res Clin Gastroenterol. 2015 Oct;29(5):783-792. doi: 10.1016/j.bpg.2015.06.014. Epub 2015 Jul 8.


Eosinophilic oesophagitis (EoE) has first been described a little over 20 years ago. EoE has been defined by a panel of international experts as a "chronic, immune/antigen-mediated, oesophageal disease, characterized clinically by symptoms related to oesophageal dysfunction and histologically by eosinophil-predominant inflammation". A value of ≥ 15 eosinophils has been defined as histologic diagnostic cutoff. Other conditions associated with oesophageal eosinophilia, such as gastro-oesophageal reflux disease (GERD), PPI-responsive oesophageal eosinophilia, or Crohn's disease should be excluded before EoE can be diagnosed. This review highlights the latest insights regarding the diagnosis and differential diagnosis of EoE.

Keywords: Eosinophilic oesophagitis; Eosinophils; PPI-responsive oesophageal eosinophilia.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Crohn Disease / diagnosis
  • Diagnosis, Differential
  • Eosinophilic Esophagitis / diagnosis*
  • Gastroesophageal Reflux / diagnosis
  • Humans