No association between use of multivitamin supplement containing vitamin D during pregnancy and risk of Type 1 Diabetes in the child

Pediatr Diabetes. 2016 Nov;17(7):525-530. doi: 10.1111/pedi.12334. Epub 2015 Nov 10.


Background: Sweden has the second highest incidence of type 1 diabetes in the world. Nutritional aspects in utero and in infancy affect the development. We conducted a survey to determine whether reported maternal use of vitamin D-containing micronutrient supplements during pregnancy was associated with the risk of developing type 1 diabetes in the child.

Methods: This report was based on data from the ABIS (All Babies In Southeast Sweden) study, with questionnaire data on 16 339 mother and infant pairs at birth and at 1-yr of age (n = 10 879), of whom 108 children were registered with type 1 diabetes before 14-16 yr of age. The questions 'during pregnancy, did you take any vitamin/mineral supplements?' and 'if yes, which? (open answer)' in addition to other lifestyle questions were answered. Logistic regression was performed with onset of type 1 diabetes as the dependent variable and vitamin D supplementation use as the independent variable, adjusted for relevant factors.

Results: Vitamin D supplementation during pregnancy was consumed by 9.3% of mothers whose children later got type1 diabetes and among 11.3% of those mothers whose children did not get type 1 diabetes (p = 0.532). No significant association was found between reported supplement intake of vitamin D during pregnancy and risk of type 1 diabetes, even when adjusting for factors which could influence the association.

Conclusion: Maternal use of vitamin D-containing multivitamin supplements during pregnancy was not related to the risk of developing type 1 diabetes in children before 14-16 yr of age in Southeast of Sweden.

Keywords: child; micronutrient; pregnancy; supplementation; type 1 diabetes; vitamin D.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Diabetes Mellitus, Type 1 / epidemiology*
  • Dietary Supplements* / adverse effects
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Maternal Nutritional Physiological Phenomena*
  • Pregnancy
  • Prenatal Exposure Delayed Effects / epidemiology*
  • Risk Factors
  • Sweden / epidemiology
  • Vitamin D / administration & dosage*
  • Vitamin D / adverse effects
  • Vitamins / administration & dosage*
  • Vitamins / adverse effects
  • Young Adult


  • Vitamins
  • Vitamin D