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Multicenter Study
. 2015 Nov 9;15:276.
doi: 10.1186/s12888-015-0656-x.

Evaluating the Impact of Cannabis Use on Thalamic Connectivity in Youth at Clinical High Risk of Psychosis

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Free PMC article
Multicenter Study

Evaluating the Impact of Cannabis Use on Thalamic Connectivity in Youth at Clinical High Risk of Psychosis

Lisa Buchy et al. BMC Psychiatry. .
Free PMC article

Abstract

Background: Disruptions in thalamic functional connectivity have been observed in people with schizophrenia and in youth at clinical high risk (CHR) of psychosis. However, the impact of environmental risk factors for psychosis on thalamic dysconnectivity is poorly understood. We tested whether thalamic dysconnectivity is related to patterns of cannabis use in a CHR sample.

Methods: 162 CHR and 105 control participants were assessed on cannabis use severity, frequency, and age at onset of first use as part of the North American Prodrome Longitudinal Study and completed resting-state fMRI scans. Whole-brain thalamic functional connectivity maps were generated using individual subjects' anatomically defined thalamic seeds.

Results: Thalamic connectivity did not significantly correlate with current cannabis use severity or frequency in either CHR or controls. In CHR cannabis users, a significant correlation emerged between attenuated thalamic connectivity with left sensory/motor cortex and a younger age at onset of cannabis use. CHR who used cannabis before age 15 did not differ on thalamic connectivity as compared to CHR who used after age 15 or CHR who were cannabis naïve. No group differences in thalamic connectivity emerged when comparing CHR separated by moderate/high use frequency, low-frequency or cannabis naïve.

Conclusions: Although a younger age at onset of cannabis use may be associated with disrupted thalamo-cortical coupling, cannabis use does not appear to be an identifying characteristic for thalamic connectivity in CHR with moderate/high use frequency compared to low-frequency users or CHR who are cannabis naïve.

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References

    1. Stephan KE, Baldeweg T, Friston KJ. Synaptic plasticity and dysconnection in schizophrenia. Biol Psychiatry. 2006;59(10):929–939. doi: 10.1016/j.biopsych.2005.10.005. - DOI - PubMed
    1. Woodward ND, Karbasforoushan H, Heckers S. Thalamocortical dysconnectivity in schizophrenia. Am J Psychiatry. 2012;169(10):1092–1099. doi: 10.1176/appi.ajp.2012.12010056. - DOI - PMC - PubMed
    1. Anticevic A, Cole MW, Repovs G, Murray JD, Brumbaugh MS, Winkler AM, et al. Characterizing Thalamo-Cortical Disturbances in Schizophrenia and Bipolar Illness. Cereb Cortex. 2013;24(12):3116–30. doi: 10.1093/cercor/bht165. - DOI - PMC - PubMed
    1. Collin G, Hulshoff Pol HE, Haijma SV, Cahn W, Kahn RS, van den Heuvel MP. Impaired cerebellar functional connectivity in schizophrenia patients and their healthy siblings. Frontiers in Psychiatry. 2011;2:73. doi: 10.3389/fpsyt.2011.00073. - DOI - PMC - PubMed
    1. Skudlarski P, Jagannathan K, Anderson K, Stevens MC, Calhoun VD, Skudlarska BA, et al. Brain connectivity is not only lower but different in schizophrenia: a combined anatomical and functional approach. Biol Psychiatry. 2010;68(1):61–69. doi: 10.1016/j.biopsych.2010.03.035. - DOI - PMC - PubMed

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