CRISPR sabotage

Genome Biol. 2015 Nov 9:16:248. doi: 10.1186/s13059-015-0820-0.

Abstract

The biological arms race generally involves the rapid co-evolution of anti-virus systems in host organisms and of anti-anti-virus systems in their viral parasites. The CRISPR-Cas system is an example of a prokaryotic immune system in which such co-evolution occurs, as was recently demonstrated by the characterization of a set of viral anti-CRISPR proteins.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • CRISPR-Cas Systems / genetics*
  • CRISPR-Cas Systems / immunology
  • Evolution, Molecular*
  • Genome, Viral / genetics
  • Genome, Viral / immunology
  • Host-Pathogen Interactions / genetics
  • Host-Pathogen Interactions / immunology
  • Humans
  • RNA Interference / immunology
  • Viral Proteins / genetics*
  • Viral Proteins / immunology

Substances

  • Viral Proteins