PDE6D binds to the C-terminus of RPGR in a prenylation-dependent manner

EMBO Rep. 2015 Dec;16(12):1581-2. doi: 10.15252/embr.201541220. Epub 2015 Nov 9.


Contrary to the prior studies, PDE6D was found to bind more preferentially to the C‐terminal prenyl moiety than the N‐terminal region of RPGR in mammalian cells. This RPGRPDE6D interaction is also dependent on the amino acid adjacent to the prenylation motif, providing an explanation as to how the specificity of PDE6D and prenylated protein interaction is determined.

Publication types

  • Letter
  • Comment

MeSH terms

  • ADP-Ribosylation Factors / chemistry*
  • Animals
  • Cyclic Nucleotide Phosphodiesterases, Type 6 / chemistry*
  • Eye Proteins / chemistry*
  • GTP-Binding Proteins / chemistry*
  • Humans


  • Eye Proteins
  • Cyclic Nucleotide Phosphodiesterases, Type 6
  • GTP-Binding Proteins
  • ADP-Ribosylation Factors