Prenatal perfluoroalkyl substance exposure and child adiposity at 8 years of age: The HOME study

Obesity (Silver Spring). 2016 Jan;24(1):231-7. doi: 10.1002/oby.21258. Epub 2015 Nov 11.


Objective: To examine relationships between prenatal perfluoroalkyl substance (PFAS) exposure and adiposity in children born to women who lived downstream from a fluoropolymer manufacturing plant.

Methods: Data are from a prospective cohort in Cincinnati, Ohio (HOME Study). Perfluorooctanoic (PFOA), perfluorooctane sulfonic (PFOS), perfluorononanoic (PFNA), and perfluorohexane sulfonic (PFHxS) acids were measured in prenatal serum samples. Differences were measured in body mass index z-scores (BMI), waist circumference, and body fat at 8 years of age (n = 204) and BMI between 2-8 years of age (n = 285) according to PFAS concentrations.

Results: Children born to women in the top two PFOA terciles had greater adiposity at 8 years than children in the 1st tercile. For example, waist circumference (cm) was higher among children in the 2nd (4.3; 95% CI: 1.7, 6.9) and 3rd tercile (2.2; 95% CI: -0.5, 4.9) compared to children in the 1st tercile. Children in the top two PFOA terciles also had greater BMI gains from 2 to 8 years compared to children in the 1st tercile (P < 0.05). PFOS, PFNA, and PFHxS were not associated with adiposity.

Conclusions: In this cohort, higher prenatal serum PFOA concentrations were associated with greater adiposity at 8 years and a more rapid increase in BMI between 2-8 years.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Alkanesulfonic Acids / adverse effects*
  • Caprylates / adverse effects*
  • Child
  • Dose-Response Relationship, Drug
  • Female
  • Fluorocarbons / adverse effects*
  • Humans
  • Longitudinal Studies
  • Ohio
  • Pediatric Obesity / chemically induced*
  • Pregnancy
  • Prenatal Exposure Delayed Effects*
  • Sulfonic Acids / adverse effects*
  • Waist Circumference


  • Alkanesulfonic Acids
  • Caprylates
  • Fluorocarbons
  • Sulfonic Acids
  • perfluorohexanesulfonic acid
  • perfluorononanoic acid
  • perfluorooctanoic acid
  • perfluorooctane sulfonic acid