Circulating Progenitor Cells and Childhood Cardiovascular Disease

Eric J Kort; Lacey Croskey; Taryn Scibienski; Surender Rajasekaran; Stefan Jovinge

doi:10.1007/s00246-015-1300-8

Circulating Progenitor Cells and Childhood Cardiovascular Disease

Pediatr Cardiol. 2016 Feb;37(2):225-31. doi: 10.1007/s00246-015-1300-8. Epub 2015 Nov 11.

Authors

Eric J Kort^{1

2

3}, Lacey Croskey⁴, Taryn Scibienski⁴, Surender Rajasekaran^{4

5}, Stefan Jovinge^{6

4

7}

Affiliations

¹ DeVos Cardiovascular Research Program of Spectrum Health and Van Andel Research Institute, 100 Michigan Street NE, Grand Rapids, MI, 49503, USA. eric.kort@vai.org.
² Michigan State University, College of Human Medicine, 15 Michigan Street NE, Grand Rapids, MI, USA. eric.kort@vai.org.
³ Helen DeVos Children's Hospital, 100 Michigan Street NE, Grand Rapids, MI, USA. eric.kort@vai.org.
⁴ Michigan State University, College of Human Medicine, 15 Michigan Street NE, Grand Rapids, MI, USA.
⁵ Helen DeVos Children's Hospital, 100 Michigan Street NE, Grand Rapids, MI, USA.
⁶ DeVos Cardiovascular Research Program of Spectrum Health and Van Andel Research Institute, 100 Michigan Street NE, Grand Rapids, MI, 49503, USA.
⁷ Cardiovascular Institute, Stanford University, Palo Alto, CA, USA.

PMID: 26554720
DOI: 10.1007/s00246-015-1300-8

Abstract

Circulating progenitor cells have been extensively studied in the context of heart disease in adults. In these patients, they have been demonstrated to be markers of myocardial injury and recovery as well as potential therapeutic agents. However, studies in children are much more limited. Here we review current knowledge pertaining to circulating progenitor cells in the context of childhood cardiovascular disease. Priorities for further research are also highlighted.

Keywords: Cardiopulmonary bypass; Congenital heart disease; Progenitor cells; Stem cells.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Cardiopulmonary Bypass
Cardiovascular Diseases / physiopathology*
Child
Heart Defects, Congenital / physiopathology
Humans
Membrane Proteins / analysis
Stem Cells / cytology*

Substances

Membrane Proteins