Therapeutic drug monitoring of antimicrobials

Ann Clin Biochem. 2016 May;53(Pt 3):333-46. doi: 10.1177/0004563215618981. Epub 2015 Nov 10.


As pathology services become more centralized and automated, the measurement of therapeutic antimicrobial drugs concentrations is increasingly performed in clinical biochemistry or 'blood science' laboratories. This review outlines key groups of antimicrobial agents: aminoglycosides, glycopeptides, antifungal agents and antituberculosis agents, their role in managing infectious diseases, and the reasons why serum concentration measurement is important.

Keywords: Antimicrobial therapy; therapeutic drug monitoring.

Publication types

  • Review

MeSH terms

  • Anti-Infective Agents / adverse effects
  • Anti-Infective Agents / blood
  • Anti-Infective Agents / therapeutic use*
  • Drug Monitoring / methods*
  • Humans


  • Anti-Infective Agents