Sugar Makes Fat by Talking to SCAP

Cancer Cell. 2015 Nov 9;28(5):548-549. doi: 10.1016/j.ccell.2015.10.011.

Abstract

Elevated blood glucose promotes lipogenesis via activating SREBP transcription factors. Tumors exhibit increased glucose uptake and lipogenesis, but the mechanisms controlling this are poorly understood. In this issue of Cancer Cell, Cheng and colleagues find that glucose activates SREBP by stabilizing SCAP, a central regulator of the SREBP pathway.

Publication types

  • Comment

MeSH terms

  • Animals
  • Female
  • Humans
  • Intracellular Signaling Peptides and Proteins / metabolism*
  • Membrane Proteins / metabolism*
  • Neoplasms / metabolism*
  • Sterol Regulatory Element Binding Protein 1 / metabolism*

Substances

  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • Sterol Regulatory Element Binding Protein 1