Sugar Makes Fat by Talking to SCAP

Wei Shao; Peter J Espenshade

doi:10.1016/j.ccell.2015.10.011

Sugar Makes Fat by Talking to SCAP

Cancer Cell. 2015 Nov 9;28(5):548-549. doi: 10.1016/j.ccell.2015.10.011.

Authors

Wei Shao¹, Peter J Espenshade²

Affiliations

¹ Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
² Department of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: peter.espenshade@jhmi.edu.

Abstract

Elevated blood glucose promotes lipogenesis via activating SREBP transcription factors. Tumors exhibit increased glucose uptake and lipogenesis, but the mechanisms controlling this are poorly understood. In this issue of Cancer Cell, Cheng and colleagues find that glucose activates SREBP by stabilizing SCAP, a central regulator of the SREBP pathway.

Publication types

Comment

MeSH terms

Animals
Female
Humans
Intracellular Signaling Peptides and Proteins / metabolism*
Membrane Proteins / metabolism*
Neoplasms / metabolism*
Sterol Regulatory Element Binding Protein 1 / metabolism*

Substances

Intracellular Signaling Peptides and Proteins
Membrane Proteins
Sterol Regulatory Element Binding Protein 1

Grant support

R01 HL077588/HL/NHLBI NIH HHS/United States