The Effects of Aerobic Exercise on Cognitive Function of Alzheimer's Disease Patients

CNS Neurol Disord Drug Targets. 2015;14(10):1292-7. doi: 10.2174/1871527315666151111123319.


To evaluate the effect of moderate intensity of aerobic exercise on elderly people with mild Alzheimer's disease, we recruited fifty volunteers aged 50 years to 80 years with cognitive impairment. They were randomized into two groups: aerobic group (n=25) or control group (n=25). The aerobic group was treated with cycling training at 70% of maximal intensity for 40 min/d, 3 d/wk for 3 months. The control group was only treated with heath education. Both groups were received cognitive evaluation, laboratory examination before and after 3 months. The results showed that the Minimum Mental State Examination score, Quality of Life Alzheimer's Disease score and the plasma Apo-a1 level was significantly increased (P<0.05), the Alzheimer's Disease Assessment Scale-cognition score, Neuropsychiatric Inventory Questionnaire score was significantly decreased.(P<0.05) in aerobic group before and after 3 months in aerobic group. For the control group, there was no significant difference in scores of Alzheimer's Disease Assessment Scale-cognition, Neuropsychiatric Inventory Questionnaire, Quality of Life Alzheimer's Disease, Apo-a1 (P>0.05), while Minimum Mental State Examination scores decreased significantly after 3 months (P<0.05). In conclusion, moderate intensity of aerobic exercise can improve cognitive function in patients with mild Alzheimer's disease.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / physiopathology
  • Alzheimer Disease / therapy*
  • Apolipoprotein A-I / blood
  • Bicycling / physiology
  • Bicycling / psychology
  • Cognition Disorders / physiopathology
  • Cognition Disorders / therapy*
  • Cognition* / physiology
  • Exercise / physiology
  • Exercise / psychology
  • Exercise Therapy* / methods
  • Female
  • Humans
  • Male
  • Mental Status Schedule
  • Neuropsychological Tests
  • Quality of Life


  • APOA1 protein, human
  • Apolipoprotein A-I