MicroRNA-34 Family and Its Role in Cardiovascular Disease

Crit Rev Eukaryot Gene Expr. 2015;25(4):293-7. doi: 10.1615/critreveukaryotgeneexpr.2015015396.


MicroRNAs (miRNAs) have been considered important regulators in both physiological and disease contexts. Among all miRNAs, the miR-34 family (miR-34a, -34b, -34c), which has been well characterized as a tumor suppressor, displays diverse functions in noncancerous diseases. MiR-34 levels are relatively low in the cardiovascular system, but recently they have been reported to function in cardiovascular disorders by regulating apoptosis, telomere attrition, DNA damage, and inflammatory response. In this review, we mainly summarize their roles in cardiac senescence and ischemic diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / genetics*
  • Cardiovascular Diseases / pathology
  • Humans
  • MicroRNAs / chemistry
  • MicroRNAs / metabolism*
  • Myocardium / pathology
  • RNA Interference
  • Tumor Suppressor Protein p53 / metabolism


  • MicroRNAs
  • Tumor Suppressor Protein p53