Lymphocytes treated with natural alfa-interferon produce a chemotactic factor for human neutrophils

Cell Biol Int Rep. 1989 Feb;13(2):163-9. doi: 10.1016/0309-1651(89)90062-3.

Abstract

Lymphocytes stimulated with alfa-interferon released a chemotactic factor for neutrophils. The process was not inhibited by cycloheximide, whereas mepacrine completely inhibited release of the chemotactic activity. The chemotactic factor was resistant to storage, heat treatment and proteolysis. Recombinant alfa-interferon did not stimulate lymphocytes to release a neutrophil chemotactic factor.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cells, Cultured
  • Chemotactic Factors / biosynthesis*
  • Chemotactic Factors / pharmacology
  • Chemotaxis, Leukocyte*
  • Culture Media
  • Cycloheximide / pharmacology
  • Humans
  • Interferon Type I / pharmacology*
  • Interleukin-8
  • Lymphocytes / metabolism*
  • Neutrophils / physiology*
  • Quinacrine / pharmacology
  • Recombinant Proteins

Substances

  • Chemotactic Factors
  • Culture Media
  • Interferon Type I
  • Interleukin-8
  • Recombinant Proteins
  • Cycloheximide
  • Quinacrine