The Path to Cancer --Three Strikes and You're Out

N Engl J Med. 2015 Nov 12;373(20):1895-8. doi: 10.1056/NEJMp1508811.


Focusing on driver-gene mutations and the pathways they control has rendered complex cancer-genome landscapes intelligible. In solid tumors of adults, alterations in as few as three driver genes appear to suffice for a cell to evolve into an advanced cancer.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cell Transformation, Neoplastic / genetics*
  • Cell Transformation, Neoplastic / metabolism
  • Humans
  • Metabolic Networks and Pathways
  • Mutation*
  • Neoplasms / genetics*
  • Precancerous Conditions / genetics