The purpose of this Rapid Response report is to summarize the evidence of clinical efficacy and harms associated with evidence of efficacy and safety of long-term nabilone use in adult populations with post-traumatic stress disorder (PTSD) and other chronic conditions.
Copyright © 2015 Canadian Agency for Drugs and Technologies in Health.
- CONTEXT AND POLICY ISSUES
- RESEARCH QUESTIONS
- KEY FINDINGS
- SUMMARY OF EVIDENCE
- CONCLUSIONS AND IMPLICATIONS FOR DECISION OR POLICY MAKING
- APPENDIX 1 Selection of Included Studies
- APPENDIX 2 Characteristics of Included Publications
- APPENDIX 3 Critical Appraisal of Included Publications
- APPENDIX 4 Main Study Findings and Author’s Conclusions
Use of a Synthetic Cannabinoid in a Correctional Population for Posttraumatic Stress Disorder-Related Insomnia and Nightmares, Chronic Pain, Harm Reduction, and Other Indications: A Retrospective EvaluationC Cameron et al. J Clin Psychopharmacol 34 (5), 559-64. PMID 24987795.Nabilone is a synthetic cannabinoid that has shown promise for the treatment of posttraumatic stress disorder (PTSD)-related insomnia and nightmares as well as efficacy i …
[Posttraumatic Stress Disorder (PTSD) as a Consequence of the Interaction Between an Individual Genetic Susceptibility, a Traumatogenic Event and a Social Context]Y Auxéméry. Encephale 38 (5), 373-80. PMID 23062450. - ReviewChronic PTSD can manifest itself in different clinical forms. The repetition syndrome can appear a long time after the traumatic event, following a paucisymptomatic laten …
A Multi-Site Single Blind Clinical Study to Compare the Effects of Prolonged Exposure, Eye Movement Desensitization and Reprocessing and Waiting List on Patients With a Current Diagnosis of Psychosis and Co Morbid Post Traumatic Stress Disorder: Study Protocol for the Randomized Controlled Trial Treating Trauma in PsychosisPA de Bont et al. Trials 14, 151. PMID 23702050. - Randomized Controlled TrialTrial registration: ISRCTN79584912.
Evidence-based Pharmacotherapy of Post-Traumatic Stress Disorder (PTSD)JC Ipser et al. Int J Neuropsychopharmacol 15 (6), 825-40. PMID 21798109. - ReviewPost-traumatic stress disorder (PTSD) is a prevalent and disabling disorder. Recognition of neurobiological abnormalities associated with this condition suggests the pote …
The Mediating Effect of Self-Efficacy in the Relationship Between Social Support and Post-Traumatic Stress Disorder Symptoms Among Patients With Central System Tumors in China: A Cross-Sectional StudyY Wang et al. Psychooncology 24 (12), 1701-7. PMID 25958841.Self-efficacy partially mediated the relationship between social support and PTSD symptoms. Interventions focusing on both social support and self-efficacy might be more …