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Randomized Controlled Trial
. 2015 Dec;18(12):1340-8.
doi: 10.1089/jmf.2015.0022. Epub 2015 Nov 12.

Dietary Supplementation With Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology

Free PMC article
Randomized Controlled Trial

Dietary Supplementation With Specific Collagen Peptides Has a Body Mass Index-Dependent Beneficial Effect on Cellulite Morphology

Michael Schunck et al. J Med Food. .
Free PMC article


In this double-blind, placebo-controlled clinical study, we investigated the efficacy of specific bioactive collagen peptides (BCP) on the cellulite treatment of normal and overweight women. In total, 105 women aged 24-50 years with moderate cellulite were randomized to orally receive a daily dosage of 2.5 g BCP or a placebo over 6 months. The degree of cellulite was evaluated before starting the treatment and after 3 and 6 months of intake. In addition, skin waviness, dermal density, and the length of subcutaneous borderline were assessed. BCP treatment led to a statistically significant decrease in the degree of cellulite and a reduced skin waviness on thighs (P < 0.05) in normal weight women. Moreover, dermal density was significantly improved (P < 0.05) compared to placebo. The subcutaneous borderline showed a significant shortening after BCP intake compared to the beginning of the study, indicating cellulite improvement, but the data failed to reach statistical significance compared to placebo. The efficacy of BCP treatment was also confirmed in overweight women, although the impact was less pronounced in comparison with women of normal body weight. The results of the study demonstrated that a regular ingestion of BCP over a period of 6 months led to a clear improvement of the skin appearance in women suffering from moderate cellulite. Based on the current data, it can be concluded that a long-term therapy with orally administered BCP leads to an improvement of cellulite and has a positive impact on skin health.

Keywords: bioactive collagen peptide; body mass index; cellulite; collagen hydrolysate; dermis density; dietary supplement; oral administration; randomized controlled clinical trial.


<b>FIG. 1.</b>
FIG. 1.
Skin surface profile of tight skin before and after 3 and 6 months of oral supplementation with bioactive collagen peptide (BCP) or placebo, measured by PRIMOS® Pico. Skin waviness of thigh was statistically significantly decreased (P < 0.05) after 6 months of BCP daily intake in the overall study subjects in comparison with placebo treatment (mean ± standard error of mean, n.s. not statistically significant).
<b>FIG. 2.</b>
FIG. 2.
Representative 3D color-coded height images of tight skin surface, before (t0) and after 6 months (t6) of oral supplementation with BCP or placebo; measured by PRIMOS Pico. Each color is related to a height with red and yellow areas, indicating the skin depression and relief as for skin surface, respectively. At the external margins of the measuring fields, the resolution is limited seen by lower intensity in green and blue. (A) Placebo group. (B) BCP group. A notable improvement in skin waviness can be seen in the BCP group, showing more homogeneous skin surfaces.
<b>FIG. 3.</b>
FIG. 3.
Dermis density of cellulite-affected area in tights after 6 months of BCP or placebo intake, measured by DermaScan. (A) Representative ultrasound cross-sectional images (single B scan) of BCP and placebo groups. The epidermis of the skin pictures is left located (yellow line). The dermis connective tissues are showing several degrees of dermal density (green low and red to yellow high density). Black structures are fat and lymphatic fluid. Note that before therapy (baseline), the interface between the dermis and the subcutis appears as a broken and irregular line and many black areas appear. After 6 months of BCP daily supplementation, dermis tissue has become measurably more compact, indicating a strengthening of the connective tissue. Black interspaces have been reduced. (B) Relative dermis density of BCP group to placebo, showing an increased dermal density after BCP treatment (7.29–7.66).

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