Metabolic Determinants of Mitochondrial Function in Oocytes

Semin Reprod Med. 2015 Nov;33(6):396-400. doi: 10.1055/s-0035-1567822. Epub 2015 Nov 12.

Abstract

Mitochondrial production of cellular energy is essential to oocyte function, zygote development and successful continuation of pregnancy. This review focuses on several key functions of healthy oocyte mitochondria and the effect of pathologic states such as aging, oxidative stress and apoptosis on these functions. The effect of these abnormal conditions is presented in terms of clinical presentations, specifically maternal obesity, diminished ovarian reserve and assisted reproductive technologies.

Publication types

  • Review

MeSH terms

  • Age Factors
  • Aging / genetics
  • Aging / metabolism*
  • Aging / pathology
  • Animals
  • Apoptosis
  • Calcium Signaling
  • Cellular Senescence* / genetics
  • DNA Damage
  • DNA, Mitochondrial / genetics
  • DNA, Mitochondrial / metabolism
  • Energy Metabolism* / genetics
  • Female
  • Fertility
  • Humans
  • Infertility, Female / genetics
  • Infertility, Female / metabolism
  • Infertility, Female / physiopathology
  • Infertility, Female / therapy
  • Mitochondria / metabolism*
  • Mitochondria / pathology
  • Oocytes / metabolism*
  • Oocytes / pathology
  • Ovarian Reserve
  • Ovary / metabolism
  • Ovary / pathology
  • Ovary / physiopathology
  • Oxidative Stress
  • Pregnancy
  • Reproductive Techniques, Assisted

Substances

  • DNA, Mitochondrial