miR-761 inhibits tumor progression by targeting MSI1 in ovarian carcinoma

Tumour Biol. 2016 Apr;37(4):5437-43. doi: 10.1007/s13277-015-4377-z. Epub 2015 Nov 12.


Increasing evidences have revealed that microRNAs regulate various biological processes. However, the roles of miR-761 have not been investigated in ovarian cancer. Here, we found that miR-761 expression was significantly lower in ovarian cancer tissues than in their paired noncancerous tissues. Further study revealed that miR-761 overexpression inhibited the ovarian cancer cell proliferation and invasion. Mechanistically, we demonstrated that the oncogenic properties of miR-761 in ovarian cancer were mediated in part by regulating MSI1 expression. miR-761 and MSI1 are inversely expressed in ovarian cancer tissues. In conclusion, we demonstrated that miR-761 repressed ovarian cancer proliferation and invasion by targeting MSI1.

Keywords: Musashi1; Ovarian cancer; miR-761; microRNAs.

MeSH terms

  • Biomarkers, Tumor / biosynthesis*
  • Biomarkers, Tumor / genetics
  • Carcinoma / genetics*
  • Carcinoma / pathology
  • Cell Line, Tumor
  • Cell Proliferation / genetics
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • MicroRNAs / biosynthesis*
  • MicroRNAs / genetics
  • Nerve Tissue Proteins / biosynthesis*
  • Nerve Tissue Proteins / genetics
  • Ovarian Neoplasms / genetics*
  • Ovarian Neoplasms / pathology
  • RNA-Binding Proteins / biosynthesis*
  • RNA-Binding Proteins / genetics


  • Biomarkers, Tumor
  • MSI1 protein, human
  • MicroRNAs
  • Nerve Tissue Proteins
  • RNA-Binding Proteins
  • microRNA761 microRNA, human