Real-world data in the molecular era-finding the reality in the real world

Clin Pharmacol Ther. 2016 Feb;99(2):186-97. doi: 10.1002/cpt.300. Epub 2016 Jan 12.


Real-world data (RWD) promises to provide a pivotal element to the understanding of personalized medicine. However, without true representation (or the reality) of the patient-disease biosystem and its molecular contributors, RWD may hamper rather than help this advancement. In this review article, we discuss RWD vs. clinical reality and the disconnects that exist currently (emphasizing molecular medicine), and methods of closing the gaps between RWD and reality.

Publication types

  • Review

MeSH terms

  • Databases, Genetic / standards*
  • Databases, Genetic / trends
  • High-Throughput Nucleotide Sequencing
  • Humans
  • Molecular Medicine / standards*
  • Molecular Medicine / trends
  • Pharmacogenetics / standards
  • Pharmacogenetics / trends
  • Precision Medicine / standards
  • Precision Medicine / trends