Increase in adipose tissue linoleic acid of US adults in the last half century

Adv Nutr. 2015 Nov 13;6(6):660-4. doi: 10.3945/an.115.009944. Print 2015 Nov.


Linoleic acid (LA) is a bioactive fatty acid with diverse effects on human physiology and pathophysiology. LA is a major dietary fatty acid, and also one of the most abundant fatty acids in adipose tissue, where its concentration reflects dietary intake. Over the last half century in the United States, dietary LA intake has greatly increased as dietary fat sources have shifted toward polyunsaturated seed oils such as soybean oil. We have conducted a systematic literature review of studies reporting the concentration of LA in subcutaneous adipose tissue of US cohorts. Our results indicate that adipose tissue LA has increased by 136% over the last half century and that this increase is highly correlated with an increase in dietary LA intake over the same period of time.

Keywords: US; change over time; dietary linoleic acid; linoleic acid; subcutaneous adipose tissue.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Adipose Tissue / chemistry*
  • Adult
  • Diet / trends
  • Dietary Fats, Unsaturated / administration & dosage
  • Dietary Fats, Unsaturated / analysis
  • Humans
  • Linoleic Acid / administration & dosage
  • Linoleic Acid / analysis*
  • Subcutaneous Fat / chemistry
  • United States


  • Dietary Fats, Unsaturated
  • Linoleic Acid