The Role of Echinocandins in Candida Biofilm-Related Vascular Catheter Infections: In Vitro and In Vivo Model Systems

Clin Infect Dis. 2015 Dec 1;61 Suppl 6:S618-21. doi: 10.1093/cid/civ815.

Abstract

Candida biofilm-associated infections of central venous catheters are a challenging therapeutic problem. Recent in vitro and in vivo studies of the structure, formation, pathogenesis, and treatment establish a rationale for new approaches to management of these tenacious infections.

Keywords: anidulafungin; biofilm; caspofungin; echinocandin; micafungin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anidulafungin
  • Animals
  • Antifungal Agents / pharmacology
  • Antifungal Agents / therapeutic use*
  • Biofilms / drug effects*
  • Candida / drug effects*
  • Candida / physiology
  • Candidiasis / drug therapy
  • Candidiasis / microbiology
  • Caspofungin
  • Catheter-Related Infections / drug therapy*
  • Catheter-Related Infections / microbiology
  • Disease Models, Animal
  • Drug Resistance, Fungal
  • Echinocandins / pharmacology*
  • Echinocandins / therapeutic use*
  • Humans
  • Lipopeptides / pharmacology
  • Lipopeptides / therapeutic use
  • Micafungin
  • Microbial Sensitivity Tests
  • Vascular Access Devices*

Substances

  • Antifungal Agents
  • Echinocandins
  • Lipopeptides
  • Anidulafungin
  • Caspofungin
  • Micafungin