Pharmacogenomic agreement between two cancer cell line data sets

Nature. 2015 Dec 3;528(7580):84-7. doi: 10.1038/nature15736. Epub 2015 Nov 16.


Large cancer cell line collections broadly capture the genomic diversity of human cancers and provide valuable insight into anti-cancer drug response. Here we show substantial agreement and biological consilience between drug sensitivity measurements and their associated genomic predictors from two publicly available large-scale pharmacogenomics resources: The Cancer Cell Line Encyclopedia and the Genomics of Drug Sensitivity in Cancer databases.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor / drug effects*
  • Databases, Factual*
  • Datasets as Topic
  • Humans
  • Inhibitory Concentration 50
  • Neoplasms / drug therapy
  • Neoplasms / genetics*
  • Neoplasms / pathology*
  • Pharmacogenetics*
  • Reproducibility of Results