Movement Disorders From the Use of Metoclopramide and Other Antiemetics in the Treatment of Migraine

Headache. 2016 Jan;56(1):153-61. doi: 10.1111/head.12712. Epub 2015 Nov 17.


Nausea and vomiting are a frequent accompaniment of migraine and anti-nausea medications are frequently used in its management. The majority of anti-nausea medications that are used in migraine are dopamine receptor blocking agents and therefore have the potential to cause drug-induced movement disorders. This article explores the risk of such drug-induced movement disorders in migraineurs who were treated with these medications.

Keywords: acute dystonic reaction; akathisia; metoclopramide; migraine; prochlorperazine; promethazine; tardive dyskinesia.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Dihydroergotamine / adverse effects*
  • Dopamine Agonists / adverse effects*
  • Dopamine D2 Receptor Antagonists / adverse effects*
  • Expert Testimony
  • Female
  • Humans
  • Metoclopramide / adverse effects*
  • Migraine Disorders / drug therapy
  • Movement Disorders / etiology*


  • Dopamine Agonists
  • Dopamine D2 Receptor Antagonists
  • Dihydroergotamine
  • Metoclopramide