Glycine reverses the effect of HA-966 on NMDA responses in cultured rat cortical neurons and in chick retina

Neurosci Lett. 1989 Apr 10;98(3):333-8. doi: 10.1016/0304-3940(89)90424-2.

Abstract

The effects of glycine on NMDA antagonism by a series of excitatory amino acid antagonists were tested in two functional in vitro models: NMDA induced [3H]GABA release from cultured mouse cortical neurons and NMDA evoked spreading depression in chick retina. In both models glycine reversed the NMDA antagonism by HA-966. Also NMDA block by kynurenic acid and by DNQX were partly reversed by glycine. However, CNQX, D-APV, ketamine and MK 801 showed the same NMDA antagonism in the absence and presence of glycine.

MeSH terms

  • Animals
  • Aspartic Acid / analogs & derivatives*
  • Aspartic Acid / antagonists & inhibitors
  • Cerebral Cortex / drug effects
  • Chickens
  • Cortical Spreading Depression / drug effects
  • Glycine / antagonists & inhibitors
  • Glycine / pharmacology*
  • In Vitro Techniques
  • N-Methylaspartate
  • Neurons / drug effects
  • Pyrrolidinones / pharmacology*
  • Rats
  • Retina / drug effects

Substances

  • Pyrrolidinones
  • Aspartic Acid
  • N-Methylaspartate
  • 1-hydroxy-3-amino-2-pyrrolidone
  • Glycine