Targeting transcription is no longer a quixotic quest

Nat Chem Biol. 2015 Dec;11(12):891-4. doi: 10.1038/nchembio.1962.


Misregulated transcription factors play prominent roles in human disease, but their dynamic protein-protein interaction network has long made the goal of transcription-targeted therapeutics impractical. Recent advances in technologies for modulating protein interaction networks mean that the end of the quest is in sight.

MeSH terms

  • Humans
  • Models, Molecular
  • Protein Binding
  • Transcription Factors / chemistry*
  • Transcription Factors / genetics
  • Transcription Factors / metabolism


  • Transcription Factors