Is Mean Platelet Volume a Reliable Marker to Predict Ischemic Stroke in the Follow-Up of Patients with Carotid Stenosis?

J Stroke Cerebrovasc Dis. 2016 Feb;25(2):404-9. doi: 10.1016/j.jstrokecerebrovasdis.2015.10.012. Epub 2015 Nov 11.


Background: The objective of the study is to evaluate the reliability of mean platelet volume (MPV) for predicting ischemic stroke (cerebrovascular event [CVE]) among patients with different degrees of carotid stenosis.

Methods: Fifty-two patients with CVEs, 136 patients with carotid artery disease (CAD), and 40 healthy volunteers were enrolled in this study. All participants were divided into the following groups according to CAD: absence of stenosis, less than 50% stenosis, 50%-69% stenosis, and 70% or more to total occlusion of the internal carotid artery. For each participant, the parameters of CAD were assessed using ultrasonography. To obtain the values of CRP and MPV and the leukocyte and platelet counts, all samples were processed within 30 minutes after blood collection. Univariate and multivariate analyses were used to evaluate the association between the values of serum C-reactive protein (CRP) and MPV and carotid stenosis.

Results: In terms of age and gender, there was no statistically significant difference between the groups (P = .094 and P = .428, respectively). However, CRP values in patients with CAD and CVEs were significantly higher than those in the controls (P < .001). There was no statistically significant difference between the CRP values in patients with CAD and CVEs (P = .249). Moreover, the MPV values did not show any significant difference between the groups (P = .053) and among the patients with CAD (P = .64). There was no positive correlation between serum CRP and MPV values in patients with CAD regarding the degree of carotid stenosis (r = .061, P = .477).

Conclusion: The findings of this study claim that MPV has no predictive value during follow-up of the patients with CAD for CVEs.

Keywords: C-reactive protein; Mean platelet volume; carotid stenosis; stroke.

MeSH terms

  • Aged
  • Biomarkers
  • Brain Ischemia / blood
  • Brain Ischemia / diagnosis*
  • Brain Ischemia / etiology
  • Carotid Stenosis / blood*
  • Carotid Stenosis / complications
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Mean Platelet Volume
  • Middle Aged
  • Predictive Value of Tests
  • Prognosis
  • Reproducibility of Results
  • Stroke / blood
  • Stroke / diagnosis*
  • Stroke / etiology


  • Biomarkers