A Rhodium Nanoparticle-Lewis Acidic Ionic Liquid Catalyst for the Chemoselective Reduction of Heteroarenes

Angew Chem Int Ed Engl. 2016 Jan 4;55(1):292-6. doi: 10.1002/anie.201507945. Epub 2015 Nov 18.

Abstract

We describe a catalytic system composed of rhodium nanoparticles immobilized in a Lewis acidic ionic liquid. The combined system catalyzes the hydrogenation of quinolines, pyridines, benzofurans, and furan to access the corresponding heterocycles, important molecules present in fine chemicals, agrochemicals, and pharmaceuticals. The catalyst is highly selective, acting only on the heteroaromatic ring, and not interfering with other reducible functional groups.

Keywords: Lewis acids; hydrogenation; ionic liquids; nanoparticle catalysis; quinolines.

Publication types

  • Research Support, Non-U.S. Gov't