SugarBindDB, a resource of glycan-mediated host-pathogen interactions

Nucleic Acids Res. 2016 Jan 4;44(D1):D1243-50. doi: 10.1093/nar/gkv1247. Epub 2015 Nov 17.


The SugarBind Database (SugarBindDB) covers knowledge of glycan binding of human pathogen lectins and adhesins. It is a curated database; each glycan-protein binding pair is associated with at least one published reference. The core data element of SugarBindDB is a set of three inseparable components: the pathogenic agent, a lectin/adhesin and a glycan ligand. Each entity (agent, lectin or ligand) is described by a range of properties that are summarized in an entity-dedicated page. Several search, navigation and visualisation tools are implemented to investigate the functional role of glycans in pathogen binding. The database is cross-linked to protein and glycan-relaled resources such as UniProtKB and UniCarbKB. It is tightly bound to the latter via a substructure search tool that maps each ligand to full structures where it occurs. Thus, a glycan-lectin binding pair of SugarBindDB can lead to the identification of a glycan-mediated protein-protein interaction, that is, a lectin-glycoprotein interaction, via substructure search and the knowledge of site-specific glycosylation stored in UniCarbKB. SugarBindDB is accessible at:

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacterial Proteins / metabolism
  • Databases, Chemical*
  • Host-Pathogen Interactions*
  • Lectins / chemistry
  • Lectins / metabolism*
  • Ligands
  • Polysaccharides / chemistry
  • Polysaccharides / metabolism*
  • Protein Binding
  • Viral Proteins / metabolism


  • Bacterial Proteins
  • Lectins
  • Ligands
  • Polysaccharides
  • Viral Proteins