Hydrogen sulfide prodrugs-a review

Acta Pharm Sin B. 2015 Sep;5(5):367-77. doi: 10.1016/j.apsb.2015.06.004. Epub 2015 Aug 21.


Hydrogen sulfide (H2S) is recognized as one of three gasotransmitters together with nitric oxide (NO) and carbon monoxide (CO). As a signaling molecule, H2S plays an important role in physiology and shows great potential in pharmaceutical applications. Along this line, there is a need for the development of H2S prodrugs for various reasons. In this review, we summarize different H2S prodrugs, their chemical properties, and some of their potential therapeutic applications.

Keywords: Controllable H2S prodrugs; Gasotransmitters; H2S prodrugs; H2S-hybrid nonsteroidal anti-inflammatory drugs; Hydrogen sulfide (H2S); Hydrolysis-based H2S prodrugs.

Publication types

  • Review