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Case Reports
. 2015 Nov 3;2:79.
doi: 10.3389/fmed.2015.00079. eCollection 2015.

Immune Thrombocytopenic Purpura Secondary to Cytomegalovirus Infection: A Case Report

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Free PMC article
Case Reports

Immune Thrombocytopenic Purpura Secondary to Cytomegalovirus Infection: A Case Report

Bessy S Flores-Chang et al. Front Med (Lausanne). .
Free PMC article

Abstract

Immune thrombocytopenic purpura (ITP) is defined as an acquired thrombocytopenia with antibodies detected against platelet surface antigens, and it is the most common form of thrombocytopenia in otherwise asymptomatic adults. ITP secondary to an underlying condition is a diagnosis of exclusion that is essential to establish for treatment efficacy. Secondary thrombocytopenia caused by cytomegalovirus (CMV) is common; however, case reports associated with diagnosis in immunocompetent adults are rare, and to the best of our knowledge only 20 publications have been associated with this diagnosis. Our report is based on a clinical presentation of a 37-year-old female complaining of petechiae, heavy menses, shortness of breath, and a platelet count of 1 × 10(9)/L. Treatment with IVIG and steroids failed to improve platelet count. Subsequently, an infectious laboratory workup was performed, detecting CMV infection, and treatment with antiviral agents was initiated, causing platelet count to increase as viral load decreased.

Keywords: bleeding; cytomegalovirus; immune thrombocytopenic purpura; steroids; valgancyclovir.

Figures

Figure 1
Figure 1
Platelet count before and after treatment. Graph representing the trend of platelet count from the time of admission to the post treatment period with valgancyclovir, romiplostim, and IVIG.
Figure 2
Figure 2
Viral load before and after treatment. Viral load in copies/MI for Cytomegalovirus (CMV) measured at admission, post treatment with valgancyclovir and during follow-up.

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