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, 8 (5), 551-61

Flexible Regression Models With Cubic Splines

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Flexible Regression Models With Cubic Splines

S Durrleman et al. Stat Med.

Abstract

We describe the use of cubic splines in regression models to represent the relationship between the response variable and a vector of covariates. This simple method can help prevent the problems that result from inappropriate linearity assumptions. We compare restricted cubic spline regression to non-parametric procedures for characterizing the relationship between age and survival in the Stanford Heart Transplant data. We also provide an illustrative example in cancer therapeutics.

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