Uromodulin, kidney function, cardiovascular disease, and mortality

Kidney Int. 2015 Nov;88(5):944-6. doi: 10.1038/ki.2015.267.


Uromodulin (Tamm-Horsfall protein) is exclusively produced by the kidney and is the most abundant protein excreted in normal urine. The level of uromodulin in urine could represent a useful biomarker for renal tubular function. The study of Garimella et al. adds elements into the debate, by suggesting that, in elderly adults, low urinary uromodulin concentrations in spot urine identify people at risk of progressive kidney disease and mortality above and beyond established markers of kidney disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Biomarkers / urine
  • Cardiovascular Diseases / metabolism
  • Humans
  • Kidney / metabolism
  • Kidney Diseases / metabolism*
  • Uromodulin / urine*


  • Biomarkers
  • Uromodulin