A new method testing the orthogonality of different protecting groups

Károly Ágoston; Ágnes Ágoston; Colin R Dorgan; Péter Fügedi

doi:10.1016/j.carres.2015.10.007

A new method testing the orthogonality of different protecting groups

Carbohydr Res. 2015 Dec 11:418:98-103. doi: 10.1016/j.carres.2015.10.007. Epub 2015 Oct 23.

Authors

Károly Ágoston¹, Ágnes Ágoston², Colin R Dorgan³, Péter Fügedi⁴

Affiliations

¹ Institute of Organic Chemistry, RCNS-HAS, Magyar Tudósok Körútja 2, 1117 Budapest, Hungary; Carbosynth LTD, 8&9 Old Station Business Park, RG20 6NE Compton, UK. Electronic address: karoly.agoston@carbosynth.com.
² Lab-Comp LTD, Rákos Tér 23/A, 1142 Budapest, Hungary.
³ Carbosynth LTD, 8&9 Old Station Business Park, RG20 6NE Compton, UK.
⁴ Institute of Organic Chemistry, RCNS-HAS, Magyar Tudósok Körútja 2, 1117 Budapest, Hungary.

PMID: 26580711
DOI: 10.1016/j.carres.2015.10.007

Abstract

A new test was elaborated to identify a new set of orthogonal protecting groups. With the developed method eight different protecting groups were tested under various deprotection conditions and the complex reaction mixtures were analysed by HPLC. The developed method allows for quick identification of orthogonality using simple model structures.

Keywords: Method development; Orthogonal protection; Protecting groups.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biological Products / chemical synthesis
Biological Products / chemistry*
Chromatography, High Pressure Liquid / methods*
Glucosides / chemical synthesis
Glucosides / chemistry*
Molecular Conformation

Substances

Biological Products
Glucosides