Primary Diffuse Large B-cell Lymphoma involving the Mandible

J Contemp Dent Pract. 2015 Oct 1;16(10):840-4. doi: 10.5005/jp-journals-10024-1767.


Lymphomas of the oral cavity are rare and typically present as intraosseous lesions that are most commonly diffuse large B-cell type. Diffuse large B-cell lymphoma (DLBCL) is an aggressive B-cell lymphoma histologically characterized by diffuse proliferation of large neoplastic B-lymphoid cells with a nuclear size equal to or exceeding normal histiocytic nuclei. A case of DLBCL of the mandible in an 18 years old male patient is presented. This report discusses this rare malignancy, including clinical presentation, histopathologic features, immunologic profile, treatment and prognosis. Though lymphoma of mandible is rare, it must be considered in differential diagnosis of swellings arising in the region.

Keywords: B-cell lymphoma; Diffuse large B-cell lymphoma; Intraosseous lymphoma; Mandible; Non-Hodgkin’s lymphoma.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Cell Nucleus
  • Diagnosis, Differential
  • Humans
  • Lymphoma, Large B-Cell, Diffuse / diagnosis*
  • Lymphoma, Large B-Cell, Diffuse / therapy
  • Male
  • Mandible*
  • Mandibular Neoplasms / diagnosis*
  • Mandibular Neoplasms / therapy