The final goal of a histopathological examination is to access the course of the presenting lesion. Histopathology is considered the gold standard in segregating benign and malignant entities, but its use in grading oral epithelial dysplasia (OED) has been a constant debate. Interobserver agreement in most studies on OED has averaged between poor to fair. Application of molecular predictive model could solve the disagreement at the histopathological level. But, in order to conduct genetic analysis, it is vital to categorize the entities based on the current diagnostic gold standard, which in turn is histopathological grading. Thus, improvising the standard of histopathological grading would aid in formulating a much reliable molecular predictive model.(1).