TERRA and the state of the telomere

Nat Struct Mol Biol. 2015 Nov;22(11):853-8. doi: 10.1038/nsmb.3078.

Abstract

Long noncoding telomeric repeat-containing RNA (TERRA) has been implicated in telomere maintenance in a telomerase-dependent and a telomerase-independent manner during replicative senescence and cancer. TERRA's proposed activities are diverse, thus making it difficult to pinpoint the critical roles that TERRA may have. We propose that TERRA orchestrates different activities at chromosome ends in a manner that depends on the state of the telomere.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Eukaryota / physiology*
  • Models, Biological
  • RNA, Untranslated / metabolism*
  • Telomerase / metabolism*
  • Telomere Homeostasis*

Substances

  • RNA, Untranslated
  • Telomerase