Mouse mutants provide new insights into the role of extracellular matrix in cell migration and differentiation

Trends Genet. 1989 Apr;5(4):116-21. doi: 10.1016/0168-9525(89)90042-5.


Migratory cell populations in the developing embryo disperse, localize and eventually differentiate in environments rich in extracellular matrix material. The extracellular matrix provides both a substratum for migration and a source of differentiative cues for the developing cells. Mutations in mice and other animals that alter embryonic interstitial environments are now providing information about the role of the extracellular matrix in these early developmental processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Movement
  • Embryonic and Fetal Development*
  • Extracellular Matrix / physiology*
  • Genes
  • Genes, Lethal
  • Hair Color
  • Mice
  • Mice, Mutant Strains / embryology
  • Mice, Mutant Strains / genetics*