DNA Repair

Angew Chem Int Ed Engl. 2015 Dec 14;54(51):15330-3. doi: 10.1002/anie.201509770. Epub 2015 Nov 19.

Abstract

DNA is constantly damaged by various endogenous and exogenous events. Repair systems constantly scan the genome for DNA lesions and replace damaged and mismatched bases, which finally enables the complex DNA double strand to store genetic information. This year's Nobel Prize in Chemistry was awarded to pioneers in this field, T. Lindahl, P. Modrich, and A. Sancar.

Keywords: DNA damage; DNA repair; biochemistry; genetic information; medicinal chemistry.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Crystallography
  • DNA / chemistry
  • DNA Repair*
  • Nucleic Acid Conformation
  • Oxidative Stress

Substances

  • DNA