Innate Immune Factors in Mothers' Breast Milk and Their Lack of Association With Rotavirus Vaccine Immunogenicity in Nicaraguan Infants

J Pediatric Infect Dis Soc. 2017 Mar 1;6(1):87-90. doi: 10.1093/jpids/piv076.

Abstract

To better understand underlying causes of lower rotavirus vaccine effectiveness in low-middle income countries (LMICs), we measured innate antiviral factors in Nicaraguan mothers' milk and immune response to the first dose of the pentavalent rotavirus vaccine in corresponding infants. No relationship was found between concentrations of innate factors and rotavirus vaccine response.

Keywords: Nicaragua; breast milk; innate immunity; lactadherin; lactoferrin; rotavirus vaccines.

MeSH terms

  • Developing Countries
  • Diphtheria-Tetanus-Pertussis Vaccine / administration & dosage
  • Diphtheria-Tetanus-Pertussis Vaccine / immunology*
  • Female
  • Haemophilus Vaccines / administration & dosage
  • Haemophilus Vaccines / immunology*
  • Humans
  • Immunity, Innate / immunology*
  • Immunogenicity, Vaccine / immunology
  • Infant
  • Male
  • Milk, Human / immunology*
  • Nicaragua
  • Poliovirus Vaccine, Inactivated / administration & dosage
  • Poliovirus Vaccine, Inactivated / immunology*
  • Treatment Outcome
  • Vaccines, Combined / administration & dosage
  • Vaccines, Combined / immunology

Substances

  • Diphtheria-Tetanus-Pertussis Vaccine
  • Haemophilus Vaccines
  • Pentavac
  • Poliovirus Vaccine, Inactivated
  • Vaccines, Combined