Kinetics of Serologic Responses to MERS Coronavirus Infection in Humans, South Korea

Emerg Infect Dis. 2015 Dec;21(12):2186-9. doi: 10.3201/eid2112.151421.


We investigated the kinetics of serologic responses to Middle East respiratory syndrome coronavirus (MERS-CoV) infection by using virus neutralization and MERS-CoV S1 IgG ELISA tests. In most patients, robust antibody responses developed by the third week of illness. Delayed antibody responses with the neutralization test were associated with more severe disease.

Keywords: MERS; MERS-CoV; Middle East respiratory syndrome; Middle East respiratory syndrome coronavirus; South Korea; antibody; clinical correlates; coronavirus; diagnostics; humans; immunity; kinetics; seroepidemiologic data; serologic responses; severity; viruses.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Viral / immunology*
  • Antibody Affinity
  • Antibody Formation / immunology
  • Camelus / immunology
  • Coronavirus Infections / epidemiology
  • Coronavirus Infections / immunology*
  • Coronavirus Infections / pathology
  • Female
  • Humans / blood
  • Humans / virology
  • Kinetics
  • Male
  • Middle East Respiratory Syndrome Coronavirus / immunology*
  • Middle East Respiratory Syndrome Coronavirus / pathogenicity*
  • Republic of Korea / epidemiology


  • Antibodies, Viral